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Article

QTL With Pleiotropic Effects on Serum Levels of Bone-Specific Alkaline Phosphatase and Osteocalcin Maps to the Baboon Ortholog of Human Chromosome 6p23-21.3

29 Sept 2006

Abstract excerpt

UNLABELLED: Bone ALP and OC are under partial genetic control. This study of 591 pedigreed baboons shows a QTL corresponding to human 6p23-21.3 that accounts for 25% (bone ALP) and 20% (OC) of the genetic variance. A gene affecting osteoblast activity, number, or recruitment likely resides in this area. INTRODUCTION: Serum levels of bone alkaline phosphatase (ALP) and osteocalcin (OC) reflect osteoblast activity....

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PMID: 17002583
DOI: 10.1359/jbmr.060812

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