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Article

Identification of novel VHL targets that are associated with the development of renal cell carcinoma.

Oncogene - 8 Mar 2007

Abdulrahman M, Maina E N, Morris M R, Zatyka M, Raval R R, Banks R E, Wiesener M S, Richards F M, Johnson C M, Latif F, Maher E R

Abstract excerpt

von Hippel-Lindau (VHL) disease is a dominantly inherited family cancer syndrome characterized by the development of retinal and central nervous system haemangioblastomas, renal cell carcinoma (RCC) and phaeochromocytoma. Specific germline VHL mutations may predispose to haemangioblastomas, RCC and phaeochromocytoma to a varying extent. Although dysregulation of the hypoxia-inducible transcription factor-2 and...

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Source

Identifiers

PMID: 17001320
DOI: 10.1038/sj.onc.1209932

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The von Hippel-Lindau tumor suppressor gene.Semantic proximity Read ↗

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.Semantic proximity Read ↗

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