Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones.

Oncology reports - 1 Jun 2005

Tsuchiya Mutsumi I, Okuda Heiwa, Takaki Yasuyuki, Baba Masaya, Hirai Syu-Ichi, Ohno Shigeo, Shuin Taro

Abstract excerpt

Von Hippel-Lindau (VHL) disease is associated with various missense germline mutations in the VHL tumor suppressor gene. Some are associated with type 1 VHL disease, renal cell carcinoma (RCC) without pheochromocytoma, while others are associated with type 2A or 2B VHL disease, pheochromocytoma without and with RCC, respectively. These mutations may cause substitutions of specific amino acid residue and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Gland Neoplasms
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Kidney Neoplasms

Share to Pheochromocytoma

Share to von Hippel-Lindau Disease

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 15870918

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones.PMID 15870918Read ↗

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.Semantic proximity Read ↗

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.Semantic proximity Read ↗

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.Semantic proximity Read ↗

Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes.Semantic proximity Read ↗

Systemic <i>VHL</i> gene functions and the VHL diseaseSemantic proximity Read ↗

Von Hippel–Lindau Disease: Molecular Pathological Basis, Clinical Criteria, Genetic Testing, Clinical Features of Tumors and TreatmentSemantic proximity Read ↗

Von Hippel-Lindau disease.Semantic proximity Read ↗

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney CancerSemantic proximity Read ↗

VHL, the story of a tumour suppressor gene.Semantic proximity Read ↗

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.Semantic proximity Read ↗

Role of VHL gene mutation in human cancer.Semantic proximity Read ↗

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.