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Article

Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel alpha subunit 1C in human heart tissues.

Pharmacogenetics and genomics - 1 Oct 2006

Wang Danxin, Papp Audrey C, Binkley Philip F, Johnson Julie A, Sadée Wolfgang

Abstract excerpt

OBJECTIVES: The voltage-dependent L-type calcium channel alpha-subunit 1c (Cav1.2, CACNA1C) undergoes extensive mRNA splicing, leading to numerous isoforms with different functions. L-type calcium channel blockers are used in the treatment of hypertension and arrhythmias, but response varies between individuals. We have studied the interindividual variability in mRNA expression and splicing of CACNA1C, in 65...

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Identifiers

PMID: 17001293
DOI: 10.1097/01.fpc.0000230119.34205.8a
PMCID: PMC2688811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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