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Article

Alternative splicing of voltage-gated calcium channels: from molecular biology to disease.

Pflugers Archiv : European journal of physiology - 1 Jul 2009

Liao Ping, Zhang Heng Yu, Soong Tuck Wah

Abstract excerpt

Recent developments in the diversification of voltage-gated calcium channel function center on the rapidly emerging role of the posttranscriptional mechanism of alternative splicing. A number of diseases have been found to relate to the dysfunction of alternatively spliced exons arising from either genetic mutations or alterations in the splicing machinery. Mutations in some genes associated with congenital...

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PMID: 19151996
DOI: 10.1007/s00424-009-0635-5

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