Article
Absence of calcium channel alpha1C-subunit mutation in human atrial fibrillation.
Asian cardiovascular & thoracic annals - 1 Aug 2010
Soon Jia-Lin, Ping Liao, Chua Yeow-Leng, Soong Tuck-Wah, Sin Kenny Yoong-Kong
Abstract excerpt
L-type voltage-gated calcium channel mutation or phenotypical variation resulting from alternative splicing has been associated with sudden arrhythmogenic death and heart failure. Changes in calcium current density, protein and mRNA expression have been associated with atrial fibrillation. We studied human atrium harvested from 16 cardiac surgery patients (coronary bypass and/or valve procedures) for mutation of...
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