Article
Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features.
The Journal of molecular diagnostics : JMD - 1 Jul 2007
Finberg Karin E, Sequist Lecia V, Joshi Victoria A, Muzikansky Alona, Miller Julie M, Han Moonjoo, Beheshti Javad, Chirieac Lucian R, Mark Eugene J, Iafrate A John
Abstract excerpt
Somatic mutations in the epidermal growth factor receptor gene (EGFR) are detected in a subset of lung adenocarcinomas, particularly bronchioloalveolar carcinoma (BAC) and adenocarcinoma with bronchioloalveolar features (AWBF), and correlate with clinical response to tyrosine kinase inhibitors (TKIs). In contrast, lung adenocarcinomas refractory to TKIs often have activating mutations in KRAS but lack EGFR...
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