Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3.

The Journal of cell biology - 25 Sept 2006

Wang Qiuyan, Li Lianyun, Ye Yihong

Abstract excerpt

Misfolded proteins of the endoplasmic reticulum undergo retrotranslocation to enter the cytosol where they are degraded by the proteasome. Retrotranslocation of many substrates requires an ATPase complex consisting of the p97 ATPase and a dimeric cofactor, Ufd1-Npl4. We report that efficient elimination of misfolded ER proteins also involves ataxin-3 (atx3), a p97-associated deubiquitinating enzyme mutated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Ataxin-3
Share to Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Gene Expression Regulation, Enzymologic

Share to Proteasome Endopeptidase Complex

Share to Protein Transport

Share to Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17000876
DOI: 10.1083/jcb.200605100
PMCID: PMC2064388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3.PMID 17000876Read ↗

The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.Semantic proximity Read ↗

Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding.Semantic proximity Read ↗

Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.Semantic proximity Read ↗

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.Semantic proximity Read ↗

The p97-UBXN1 complex regulates aggresome formationSemantic proximity Read ↗

Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.Semantic proximity Read ↗

ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chainsSemantic proximity Read ↗

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains.Semantic proximity Read ↗

Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death.Semantic proximity Read ↗

Mutant Ataxin-3-Containing Aggregates (MATAGGs) in Spinocerebellar Ataxia Type 3: Dynamics of the Disorder.Semantic proximity Read ↗

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.Semantic proximity Read ↗

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.