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Article

Regulation of p53 localization and activity by Ubc13.

Molecular and cellular biology - 1 Dec 2006

Laine Aaron, Topisirovic Ivan, Zhai Dayong, Reed John C, Borden Katherine L B, Ronai Ze'ev

Abstract excerpt

The abundance and activity of p53 are regulated largely by ubiquitin ligases. Here we demonstrate a previously undisclosed regulation of p53 localization and activity by Ubc13, an E2 ubiquitin-conjugating enzyme. While increasing p53 stability, Ubc13 decreases p53 transcriptional activity and increases its localization to the cytoplasm, changes that require its ubiquitin-conjugating activity. Ubc13 elicits...

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Identifiers

PMID: 17000756
DOI: 10.1128/MCB.01156-06
PMCID: PMC1636826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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