Article
Characterization of amino acid residues within the N-terminal region of Ubc9 that play a role in Ubc9 nuclear localization.
Biochemical and biophysical research communications - 27 Feb 2015
Sekhri Palak, Tao Tao, Kaplan Feige, Zhang Xiang-Dong
Abstract excerpt
As the sole E2 enzyme for SUMOylation, Ubc9 is predominantly nuclear. However, the underlying mechanisms of Ubc9 nuclear localization are still not well understood. Here we show that RNAi-depletion of Imp13, an importin known to mediate Ubc9 nuclear import, reduces both Ubc9 nuclear accumulation...
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