Article
In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling.
Human reproduction (Oxford, England) - 1 Jul 2014
Fowler Paul A, Childs Andrew J, Courant Frédérique, MacKenzie Alasdair, Rhind Stewart M, Antignac Jean-Philippe, Le Bizec Bruno, Filis Panagiotis, Evans Fergus, Flannigan Samantha, Maheshwari Abha, Bhattacharya Siladitya, Monteiro Ana, Anderson Richard A, O'Shaughnessy Peter J
Abstract excerpt
STUDY QUESTION: How does maternal cigarette smoking disturb development of the human fetal ovary? SUMMARY ANSWER: Maternal smoking increases fetal estrogen titres and dysregulates several developmental processes in the fetal ovary. WHAT IS KNOWN ALREADY: Exposure to maternal cigarette smoking during gestation reduces human fetal ovarian cell numbers, germ cell proliferation and subsequent adult fecundity. STUDY...
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