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Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother‐infant pairs

2 Mar 2006

Abstract excerpt

AIMS: To determine infant exposure to 6-thioguanine and 6-methylmercaptopurine nucleotides (6-TGN and 6-MMPN, respectively) during maternal use of azathioprine in breastfeeding. METHODS: Mother-infant pairs provided blood for determination of 6-TGN and 6-MMPN concentrations, and TPMT genotype. RESULTS: Four women taking azathioprine 1.2-2.1 mg kg(-1) day(-1) and their infants were studied. All had the wild-type...

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PMID: 16995866
DOI: 10.1111/j.1365-2125.2006.02639.x

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