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Article

A Severe Neonatal Lymphopenia Associated With Administration of Azathioprine to the Mother in a Context of Crohn's Disease.

Journal of Crohn's & colitis - 24 Jan 2018

Thomas Caroline, Monteil-Ganiere Catherine, Mirallié Sophie, Hémont Caroline, Dert Cecile, Léger Alexandra, Joyau Caroline, Caldari Dominique, Audrain Marie

Abstract excerpt

Azathioprine is commonly used in Crohn's disease. It has been administered to many pregnant women over many years without significant side effects. However, pancytopenia and severe combined immune deficiency-like disease have been reported in infants whose mothers received azathioprine throughout pregnancy. Moreover, myelotoxicity has been described in patients being treated with azathioprine and having a low or...

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Source

Identifiers

PMID: 28961694
DOI: 10.1093/ecco-jcc/jjx123

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Severe Neonatal Lymphopenia Associated With Administration of Azathioprine to the Mother in a Context of Crohn's Disease.PMID 28961694Read ↗

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Azathioprine-induced fatal myelosuppression in systemic lupus erythematosus patient carrying TPMT*3C polymorphism.Semantic proximity Read ↗

Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency.Semantic proximity Read ↗

Absence of Maternal Microchimerism in Regional Lymph Nodes of Children With Biliary Atresia.Semantic proximity Read ↗

Azathioprine-related myelosuppression in a patient homozygous for TPMT*3A.Semantic proximity Read ↗

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy.Semantic proximity Read ↗

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Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother‐infant pairsSemantic proximity Read ↗

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