Article
K88 fimbriae as carriers of heterologous antigenic determinants.
Microbial pathogenesis - 1 May 1990
Bakker D, van Zijderveld F G, van der Veen S, Oudega B, de Graaf F K
Abstract excerpt
The K88 fimbriae of enterotoxigenic Escherichia coli are strongly immunogenic antigens that can be used to evoke protective immunity. To find out whether these fimbriae can be used as carriers for foreign epitopes, a highly variable region present in the primary structure of the different K88 variants was replaced with five different heterologous epitopes to investigate to what extent these insertions affected...
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