Article
Partially assembled K99 fimbriae are required for protection.
Infection and immunity - 1 Nov 2005
Ascón Miguel A, Ochoa-Repáraz Javier, Walters Nancy, Pascual David W
Abstract excerpt
Antibodies to K99 fimbriae afford protection to F5+ bovine enterotoxigenic Escherichia coli (ETEC). Previous studies show that murine dams immunized with Salmonella vaccine vectors stably expressing K99 fimbriae confer protection to ETEC-challenged neonatal pups. To begin to address adaptation of the K99 scaffold to display heterologous B- and T-cell epitopes, studies were conducted to determine how much of the...
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