Article
The polymeric stability of the Escherichia coli F4 (K88) fimbriae enhances its mucosal immunogenicity following oral immunization.
Vaccine - 23 Oct 2008
Verdonck Frank, Joensuu Jussi Joonas, Stuyven Edith, De Meyer Julie, Muilu Mikko, Pirhonen Minna, Goddeeris Bruno Maria, Mast Jan, Niklander-Teeri Viola, Cox Eric
Abstract excerpt
Only a few vaccines are commercially available against intestinal infections since the induction of a protective intestinal immune response is difficult to achieve. For instance, oral administration of most proteins results in oral tolerance instead of an antigen-specific immune response. We have shown before that as a result of oral immunization of piglets with F4 fimbriae purified from pathogenic...
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