Article
High fidelity of RecA-catalyzed recombination: a watchdog of genetic diversity.
Nucleic acids research - 1 Jan 2006
Sagi Dror, Tlusty Tsvi, Stavans Joel
Abstract excerpt
Homologous recombination plays a key role in generating genetic diversity, while maintaining protein functionality. The mechanisms by which RecA enables a single-stranded segment of DNA to recognize a homologous tract within a whole genome are poorly understood. The scale by which homology recognition takes place is of a few tens of base pairs, after which the quest for homology is over. To study the mechanism of...
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