Article
Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.
Molecular microbiology - 1 Aug 2010
Puttikamonkul Srisombat, Willger Sven D, Grahl Nora, Perfect John R, Movahed Navid, Bothner Brian, Park Steven, Paderu Padmaja, Perlin David S, Cramer Robert A
Abstract excerpt
The trehalose biosynthesis pathway is critical for virulence in human and plant fungal pathogens. In this study, we tested the hypothesis that trehalose 6-phosphate phosphatase (T6PP) is required for Aspergillus fumigatus virulence. A mutant of the A. fumigatus T6PP, OrlA, displayed severe morphological defects related to asexual reproduction when grown on glucose (1%) minimal media. These defects could be...
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