Article
Lipooligosaccharide structure contributes to multiple steps in the virulence of Neisseria meningitidis.
Infection and immunity - 1 Feb 2006
Plant Laura, Sundqvist Johanna, Zughaier Susu, Lövkvist Lena, Stephens David S, Jonsson Ann-Beth
Abstract excerpt
Lipooligosaccharide (LOS) of Neisseria meningitidis has been implicated in meningococcal interaction with host epithelial cells and is a major factor contributing to the human proinflammatory response to meningococci. LOS mutants of the encapsulated N. meningitidis serogroup B strain NMB were use...
Topics
- Animals
- Bacterial Adhesion
- Blood
- Blood-Brain Barrier
- Carbohydrate Sequence
- Cell Line
- Cytokines
- Epithelial Cells
- Humans
- Lipopolysaccharides
- Membrane Cofactor Protein
- Meningococcal Infections
- Mice
- Mice, Transgenic
- Mutation
- Neisseria meningitidis, Serogroup B
- Pharynx