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Article

High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2006

Suzuki Toshihiko, Yoshikawa Yuko, Ashida Hiroshi, Iwai Hiroki, Toyotome Takahito, Matsui Hidenori, Sasakawa Chihiro

Abstract excerpt

Live attenuated Shigella vaccines elicit protective immune responses, but involve a potential risk of inducing a strong inflammatory reaction. The bacterial invasiveness that is crucial for Ag delivery causes inflammatory destruction of infected epithelial cells and proinflammatory cell death of infected macrophages. In this study, the noninvasive Shigella mutant DeltaipaB was equipped with Yersinia invasin...

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PMID: 16982910
DOI: 10.4049/jimmunol.177.7.4709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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