Article
Cross-protection provided by live Shigella mutants lacking major antigens.
International journal of medical microbiology : IJMM - 1 May 2013
Szijártó Valéria, Hunyadi-Gulyás Eva, Emődy Levente, Pál Tibor, Nagy Gábor
Abstract excerpt
The immune response elicited by Shigella infections is dominated by serotype-specific antibodies recognizing the LPS O-antigens. Although a marked antibody response to invasion plasmid antigens (Ipa-s) shared by all virulent strains is also induced, the varying level of immunity elicited by natural infections is serotype-restricted. Previous vaccines have tried to mimic and achieve this serotype-specific,...
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