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IQGAP1 Protein Specifies Amplifying Cancer Cells in Glioblastoma Multiforme

15 Sept 2006

Abstract excerpt

The accurate identification and thorough characterization of tumorigenic cells in glioblastomas are essential to enhance our understanding of their malignant behavior and for the design of strategies that target this important cell population. We report here that, in rat brain, the scaffolding protein IQGAP1 is a marker of brain nestin+ amplifying neural progenitor cells. In a rat model of glioma, IQGAP1 also...

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PMID: 16982749
DOI: 10.1158/0008-5472.can-06-0761

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