Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer.

doi:10.1158/0008-5472.CAN-06-0222

Article

Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer.

Cancer research - 15 Sept 2006

Pejovic Tanja, Yates Jane E, Liu Hong Y, Hays Laura E, Akkari Yassmine, Torimaru Yumi, Keeble Winifred, Rathbun R Keaney, Rodgers William H, Bale Allen E, Ameziane Najim, Zwaan C Michael, Errami Abdellatif, Thuillier Philippe, Cappuccini Fabio, Olson Susan B, Cain Joanna M, Bagby Grover C

Abstract excerpt

Fanconi anemia is an inherited cancer predisposition disease characterized by cytogenetic and cellular hypersensitivity to cross-linking agents. Seeking evidence of Fanconi anemia protein dysfunction in women at risk of ovarian cancer, we screened ovarian surface epithelial cells from 25 primary cultures established from 22 patients using cross-linker hypersensitivity assays. Samples were obtained from (a) women...

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