Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cat and mouse.

Neuron - 21 Sept 2006

Cole Greg M, Frautschy Sally A

Abstract excerpt

The role of cathepsin B, a lysosomal protease implicated in amyloid-beta (Abeta1-42) metabolism, in Alzheimer's disease remains controversial. In this issue of Neuron, Mueller-Steiner et al. manipulate the expression of cathepsin B in aged APP transgenic mice, observing that increased expression degrades preformed oligomeric and fibrillar amyloid, while inactivation accelerates beta-amyloidosis.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathepsin B

Share to Hydrolysis

Share to Neurites

Share to Peptide Fragments

Share to Plaque, Amyloid

Source

Identifiers

PMID: 16982408
DOI: 10.1016/j.neuron.2006.09.005

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cat and mouse.PMID 16982408Read ↗

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.Semantic proximity Read ↗

APP Transgenic Mice: Their Use and LimitationsSemantic proximity Read ↗

Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.Semantic proximity Read ↗

Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein.Semantic proximity Read ↗

Natural Non-Trasgenic Animal Models for Research in Alzheimers DiseaseSemantic proximity Read ↗

Murine Cathepsin F Deficiency Causes Neuronal Lipofuscinosis and Late-Onset Neurological DiseaseSemantic proximity Read ↗

Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In VivoSemantic proximity Read ↗

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesisSemantic proximity Read ↗

A canine model of Alzheimer's disease generated by overexpressing a mutated human amyloid precursor protein.Semantic proximity Read ↗

Transgenic-Mouse Model of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Differential expression of cathepsin X in aging and pathological central nervous system of miceSemantic proximity Read ↗

Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.