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Article

Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells.

Journal of neurochemistry - 1 Nov 2006

Tehranian Roya, Montoya Susana E, Van Laar Amber D, Hastings Teresa G, Perez Ruth G

Abstract excerpt

Alpha-synuclein is a presynaptic protein strongly implicated in Parkinson's disease (PD). Because dopamine neurons are invariably compromised during pathogenesis in PD, we have been exploring the functions of alpha-synuclein with particular relevance to dopaminergic neuronal cells. We previously discovered reduced tyrosine hydroxylase (TH) activity and minimal dopamine synthesis in stably-transfected MN9D cells...

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PMID: 16981894
DOI: 10.1111/j.1471-4159.2006.04146.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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