Article
Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients.
World journal of gastroenterology - 7 Sept 2006
Kalinin Viacheslav N, Kaifi Jussuf T, Schwarzenbach Heidi, Sergeyev Anatoly S, Link Bjoern C, Bogoevski Dean, Vashist Yogesh, Izbicki Jakob R, Yekebas Emre F
Abstract excerpt
AIM: To verify and expand the known spectrum of serine protease inhibitor Kazal type 1 (SPINK1) gene mutations in chronic pancreatitis. METHODS: DNA extracted from 172 chronic pancreatitis patients was assayed for SPINK1 gene mutations by PCR and DNA sequencing. A control cohort of 90 unrelated healthy individuals was analysed by the same methods for presence of common populational polymorphisms, and frequency of...
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