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Article

Molecular heterosis of prion protein beta-oligomers. A potential mechanism of human resistance to disease.

The Journal of biological chemistry - 10 Nov 2006

Tahiri-Alaoui Abdessamad, Sim Valerie L, Caughey Byron, James William

Abstract excerpt

The gene encoding prion protein is polymorphic in human populations, with over 40% of native Europeans, for example, being heterozygous for the Met-129 and Val-129 alleles. The polymorphism affects both the incidence and the clinical presentation of a range of prion diseases, with heterozygotes generally showing the highest levels of resistance. It has been suggested that an earlier epidemic of prion diseases...

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PMID: 16980300
DOI: 10.1074/jbc.M606606200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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