Article
The Distribution of Prion Protein Allotypes Differs Between Sporadic and Iatrogenic Creutzfeldt-Jakob Disease Patients.
PLoS pathogens - 1 Feb 2016
Moore Roger A, Head Mark W, Ironside James W, Ritchie Diane L, Zanusso Gianluigi, Choi Young Pyo, Pyo Choi Young, Priola Suzette A
Abstract excerpt
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent of the human prion diseases, which are fatal and transmissible neurodegenerative diseases caused by the infectious prion protein (PrP(Sc)). The origin of sCJD is unknown, although the initiating event is thought to be the stochastic misfolding of endogenous prion protein (PrP(C)) into infectious PrP(Sc). By contrast, human growth hormone-associated...
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