Article
Epidermal growth factor receptor mutations in lung adenocarcinoma.
Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2014
Siegelin Markus D, Borczuk Alain C
Abstract excerpt
Despite tremendous progress in the last decade, lung adenocarcinoma still represents a tumor with unfavorable prognosis when detected at advanced clinical stage. High-stage tumors are not amenable to surgical resection, and therefore systemic therapies are needed to control these tumors to prolong patient survival. In the era of molecular and personalized therapeutics, the discovery of mutations in epidermal...
Topics
- Adenocarcinoma
- Adenocarcinoma of Lung
- Drug Resistance, Neoplasm
- ErbB Receptors
- Gefitinib
- Gene Expression Regulation, Neoplastic
- Humans
- Lung Neoplasms
- MAP Kinase Kinase 1
- Models, Biological
- Mutation
- Protein Kinase Inhibitors
- Quinazolines
- Receptor, ErbB-2
- Signal Transduction