Article
Lung cancer genetics and pharmacogenomics.
Cytogenetic and genome research - 1 Jan 2006
Joshi V A, Kucherlapati R
Abstract excerpt
Epidermal growth factor receptor (EGFR)-targeted therapies have demonstrated remarkable success in a small subset of non-small cell lung cancer patients. The mechanism of response has been an area of active research, with somatic mutation in a number of genes in the EGFR signal transduction pathway and copy number alterations of genes of the EGFR family as candidates contributing towards response. Continuing...
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