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C5a peptidase (ScpA) activity towards human type II and type III interferons

17 May 2024

Abstract excerpt

C5a peptidase, also known as ScpA, is a surface associated serine protease derived from Streptococcus pyogenes and has been described as an important factor in streptococcus virulence, capable of cleaving complement components C5a, C3 and C3a. Although the interactions of ScpA with complement components is well studied, extensive screening of ScpA activity against other pro-inflammatory cytokines is lacking....

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PMID: 38759527
DOI: 10.1016/j.cyto.2024.156652

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