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Article

Crystal structure of the zymogen form of the group A <i>Streptococcus</i> virulence factor SpeB: An integrin-binding cysteine protease

11 Feb 2000

Abstract excerpt

Pathogenic bacteria secrete protein toxins that weaken or disable their host, and thereby act as virulence factors. We have determined the crystal structure of streptococcal pyrogenic exotoxin B (SpeB), a cysteine protease that is a major virulence factor of the human pathogen Streptococcus pyogenes and participates in invasive disease episodes, including necrotizing fasciitis. The structure, determined for the...

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PMID: 10681429
DOI: 10.1073/pnas.040549997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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