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Article

Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 1 Feb 2020

Chalmers Callum, Khemlani Adrina Hema J, Sohn Chae Ryeong, Loh Jacelyn Mei San, Tsai Catherine Jia-Yun, Proft Thomas

Abstract excerpt

BACKGROUND: Streptococcus pyogenes, or Group A Streptococcus (GAS), is a human pathogen that causes a wide range of diseases, including pharyngitis, necrotizing fasciitis and toxic shock syndrome. The bacterium produces a large arsenal of virulence factors, including the cell wall-anchored Streptococcus pyogenes nuclease A (SpnA), which facilitates immune evasion by degrading the DNA backbone of neutrophil...

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PMID: 29158081
DOI: 10.1016/j.jmii.2017.09.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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