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JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells

8 Apr 2019

Abstract excerpt

JC polyomavirus (JCPyV) is a ubiquitous human pathogen that causes progressive multifocal leukoencephalopathy (PML), a severe and often fatal neurodegenerative disease in immunocompromised or immunomodulated patients. The mechanisms responsible for initiating infection in susceptible cells are not completely known. The major attachment receptor for the virus, lactoseries tetrasaccharide c (LSTc), is paradoxically...

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PMID: 30967463
DOI: 10.1128/mbio.00379-19

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