Article
TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori-related diseases.
Genes and immunity - 1 Dec 2006
Garcia-Gonzalez M A, Strunk M, Piazuelo E, Benito R, Santolaria S, Jiménez P, Sopeña F, Pascual C, Simón M A, Sainz R, Lanas A
Abstract excerpt
Recent studies have revealed elevated expression of transforming growth factor beta1 (TGF-beta1) in gastric mucosa of patients with gastric cancer (GC) and those undergoing ulcer repair. As production of TGF-beta1 is genetically regulated, we aimed to assess whether functional polymorphisms of the TGFB1 gene are involved in susceptibility to and clinical characteristics of Helicobacter pylori-related diseases....
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