Article
Specificity of two subsets of cytotoxic human gamma delta T-cell clones.
Scandinavian journal of immunology - 1 Aug 1990
Qvigstad E, Bosnes V, Lundin K E, Thorsby E
Abstract excerpt
Peripheral blood mononuclear cells were enriched for gamma delta T cells by immunomagnetic separation, stimulated with cells from an allogeneic donor, and cloned. T-lymphocyte clones (TLC) of the two major gamma delta T-cell subsets, BB3+ (i.e. V delta 2+) and delta TCS1+ (i.e. V delta 1/(D)/J delta 1), were obtained. In addition, one gamma delta TLC was BB3- delta TCS1-. All of the BB3+ TLC showed strong...
Topics
- Antibodies, Monoclonal
- B-Lymphocytes
- Clone Cells
- Cytotoxicity, Immunologic
- Epitopes
- Humans
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, gamma-delta
- T-Lymphocytes, Cytotoxic
- Tumor Cells, Cultured