Article
Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1993
Tung L, Mohamed M K, Hoeffler J P, Takimoto G S, Horwitz K B
Abstract excerpt
When antagonist-occupied steroid receptors have agonist-like effects, the clinical consequences are grave. We present evidence that human progesterone B-receptors (hPRB) when occupied by progesterone antagonists, inappropriately activate transcription by an unusual mechanism that does not require the canonical progesterone response element (PRE). In HeLa cells cotransfected with a PRE-tk-chloramphenicol...
Topics
- Binding Sites
- DNA
- Genes, Reporter
- Genes, fos
- Genes, jun
- Gonanes
- HeLa Cells
- Humans
- Leucine Zippers
- Mifepristone
- Phenotype