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Article

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jun 2012

Gilsbach Bernd K, Ho Franz Y, Vetter Ingrid R, van Haastert Peter J M, Wittinghofer Alfred, Kortholt Arjan

Abstract excerpt

Mutations in human leucine-rich-repeat kinase 2 (LRRK2) have been found to be the most frequent cause of late-onset Parkinson disease. Here we show that Dictyostelium discoideum Roco4 is a suitable model to study the structural and biochemical characteristics of the LRRK2 kinase and can be used f...

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Identifiers

PMID: 22689969
DOI: 10.1073/pnas.1203223109
PMCID: PMC3387044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22689969-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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