Article
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jun 2012
Gilsbach Bernd K, Ho Franz Y, Vetter Ingrid R, van Haastert Peter J M, Wittinghofer Alfred, Kortholt Arjan
Abstract excerpt
Mutations in human leucine-rich-repeat kinase 2 (LRRK2) have been found to be the most frequent cause of late-onset Parkinson disease. Here we show that Dictyostelium discoideum Roco4 is a suitable model to study the structural and biochemical characteristics of the LRRK2 kinase and can be used for optimization of current and identification of new LRRK2 inhibitors. We have solved the structure of Roco4 kinase...
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