Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular switch for alternative conformations of the HIV-1 V3 region: implications for phenotype conversion.

Proceedings of the National Academy of Sciences of the United States of America - 19 Sept 2006

Rosen Osnat, Sharon Michal, Quadt-Akabayov Sabine R, Anglister Jacob

Abstract excerpt

HIV-1 coreceptor usage plays a critical role in virus tropism and pathogenesis. A switch from CCR5- to CXCR4-using viruses occurs during the course of HIV-1 infection and correlates with subsequent disease progression. A single mutation at position 322 within the V3 loop of the HIV-1 envelope gly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokines
Share to Crystallography, X-Ray
Share to HIV Envelope Protein gp120

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen Bonding

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Peptide Fragments

Share to Point Mutation

Share to Static Electricity

Source

Open in PubMed Open full text

Identifiers

PMID: 16966601
DOI: 10.1073/pnas.0606312103
PMCID: PMC1599894

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16966601-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular switch for alternative conformations of the HIV-1 V3 region: implications for phenotype conversion.PMID 16966601Read ↗

Variability in the human immunodeficiency virus type 1 gp120 Env protein linked to phenotype-associated changes in the V3 loop.Semantic proximity Read ↗

Restricted variable residues in the C-terminal segment of HIV-1 V3 loop regulate the molecular anatomy of CCR5 utilization.Semantic proximity Read ↗

Substitution of gp120 C4 region compensates for V3 loss-of-fitness mutations in HIV-1 CRF01_AE co-receptor switching.Semantic proximity Read ↗

Correlated mutations at gp120 positions 322 and 440: implications for gp120 structure.Semantic proximity Read ↗

Mutations in the V3 stem versus the V3 crown and C4 region have different effects on the binding and fusion steps of human immunodeficiency virus type 1 gp120 interaction with the CCR5 coreceptorSemantic proximity Read ↗

On the Physicochemical and Structural Modifications Associated with HIV-1 Subtype B Tropism Transition.Semantic proximity Read ↗

Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies.Semantic proximity Read ↗

Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations.Semantic proximity Read ↗

HIV-1 gp120 V3 Loop for Structure-Based Drug DesignSemantic proximity Read ↗

Molecular Recognition of CXCR4 by a Dual Tropic HIV-1 gp120 V3 LoopSemantic proximity Read ↗

Predicting HIV-1 coreceptor usage with sequence analysis.Semantic proximity Read ↗

APOBEC3G/F as one possible driving force for co-receptor switch of the human immunodeficiency virus-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.