Article
Application of BRCA1 and BRCA2 mutation carrier prediction models in breast and/or ovarian cancer families of French Canadian descent.
Clinical genetics - 1 Oct 2006
Oros K K, Ghadirian P, Maugard C M, Perret C, Paredes Y, Mes-Masson A-M, Foulkes W D, Provencher D, Tonin P N
Abstract excerpt
The BRCAPRO, Couch, Myriad I and II, Ontario Family History Assessment Tool (FHAT), and Manchester models have been used to predict BRCA1 or BRCA2 mutation carrier status of women at high risk for developing the heritable form of breast and ovarian cancers. We have evaluated these models for their accuracy in classifying 224 French Canadian families with at least three cases of breast cancer (diagnosed before the...
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