Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multistep testing approach in French-Canadian families with high risk of breast and ovarian cancer.

doi:10.1136/jmg.2006.044388

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Article

Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multistep testing approach in French-Canadian families with high risk of breast and ovarian cancer.

Journal of medical genetics - 1 Feb 2007

Simard Jacques, Dumont Martine, Moisan Anne-Marie, Gaborieau Valérie, Malouin Hélène, Durocher Francine, Chiquette Jocelyne, Plante Marie, Avard Denise, Bessette Paul, Brousseau Claire, Dorval Michel, Godard Béatrice, Houde Louis, Joly Yann, Lajoie Marie-Andrée, Leblanc Gilles, Lépine Jean, Lespérance Bernard, Vézina Hélène, Parboosingh Jillian, Pichette Roxane, Provencher Louise, Rhéaume Josée, Sinnett Daniel, Samson Carolle, Simard Jean-Claude, Tranchant Martine, Voyer Patricia, Easton Douglas, Tavtigian Sean V, Knoppers Bartha-Maria, Laframboise Rachel, Bridge Peter, Goldgar David

Abstract excerpt

BACKGROUND AND OBJECTIVE: In clinical settings with fixed resources allocated to predictive genetic testing for high-risk cancer predisposition genes, optimal strategies for mutation screening programmes are critically important. These depend on the mutation spectrum found in the population under consideration and the frequency of mutations detected as a function of the personal and family history of cancer,...

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Identifiers

PMID: 16905680
DOI: 10.1136/jmg.2006.044388
PMCID: PMC2598057

Genes

BRCA1
BRCA2

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Source receipt: pubmed, retrieved 5 Sept 2026.

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