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Article

Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a Chinese population.

European journal of cancer (Oxford, England : 1990) - 1 Dec 2006

Wang Lina, Chen Wensen, Wang Jianmin, Tan Yongfei, Zhou Yan, Ding Weiliang, Hua Zhaolai, Shen Jing, Xu Yaochu, Shen Hongbing

Abstract excerpt

Low folate intake has been associated with an increased risk of both oesophageal and gastric cancers. Reduced folate carrier (RFC1, also named SLC19A1) is an essential folate transporter and functions as a bidirectional anion exchanger, taking up folate cofactors and exporting various organic anions. A G80A polymorphism in RFC1 gene has been shown to be associated with alterations in folate and homocysteine...

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Identifiers

PMID: 16962770
DOI: 10.1016/j.ejca.2006.04.022

Genes

RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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