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Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

7 Sept 2006

Abstract excerpt

Integrative genomic and gene-expression analyses have identified amplified oncogenes in B-cell non-Hodgkin lymphoma (B-NHL), but the capability of such technologies to localize tumor suppressor genes within homozygous deletions remains unexplored. Array-based comparative genomic hybridization (CGH) and gene-expression microarray analysis of 48 cell lines derived from patients with different B-NHLs delineated 20...

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PMID: 16960149
DOI: 10.1182/blood-2006-06-026500

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