Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes.

doi:10.1182/blood-2005-05-2013

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Article

Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes.

Blood - 1 Nov 2005

Rubio-Moscardo Fanny, Blesa David, Mestre Cinta, Siebert Reiner, Balasas Theo, Benito Adalberto, Rosenwald Andreas, Climent Joan, Martinez Jose I, Schilhabel Markus, Karran E Lorraine, Gesk Stefan, Esteller Manel, deLeeuw Ronald, Staudt Louis M, Fernandez-Luna Jose Luis, Pinkel Daniel, Dyer Martin J S, Martinez-Climent Jose A

Abstract excerpt

Deletions of chromosome 8p are a recurrent event in B-cell non-Hodgkin lymphoma (B-NHL), suggesting the presence of a tumor suppressor gene. We have characterized these deletions using comparative genomic hybridization to microarrays, fluorescence in situ hybridization (FISH) mapping, DNA sequencing, and functional studies. A minimal deleted region (MDR) of 600 kb was defined in chromosome 8p21.3, with one mantle...

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PMID: 16051735
DOI: 10.1182/blood-2005-05-2013

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