Article
Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions.
Cell death and differentiation - 1 Oct 2016
Brichkina A, Nguyen N Tm, Baskar R, Wee S, Gunaratne J, Robinson R C, Bulavin D V
Abstract excerpt
The stress-induced p38 mitogen-activated protein kinase (MAPK) pathway plays an essential role in multiple physiological processes, including cancer. In turn, p38MAPK phosphorylation at Thr180 and Tyr182 is a key regulatory mechanism for its activation and functions. Here we show that this mechanism is actively regulated through isomerisation of Pro224. Different cyclophilins can isomerise this proline residue...
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