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Article

In vivo modulation of the Parkinsonian phenotype by Nrf2.

Neurotoxicology - 1 Dec 2006

Burton Neal C, Kensler Thomas W, Guilarte Tomás R

Abstract excerpt

Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of PD. In this report we show that Nrf2, a transcription factor that regulates the expression of phase 2 and antioxidative enzymes, modulates MPTP neurotoxicity in rodents. Nrf2 knockout and wild-type mice were administered MPTP doses ranging from 20 to...

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Identifiers

PMID: 16959318
DOI: 10.1016/j.neuro.2006.07.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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