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Article

Exploring allelic imbalance within paraffin-embedded tumor biopsies using pyrosequencing technology.

Clinical chemistry and laboratory medicine - 1 Jan 2006

Pascual Manuel Hidalgo, Royo José Luis, Martínez-Tello Francisco Jose, Crespo Carmen, Salinas Ana, Herrero Eduardo Ferrero, Lopez-García María, Real Luis Miguel, Ruiz Agustín, Ramirez-Lorca Reposo

Abstract excerpt

BACKGROUND: The comparison of molecular genetic changes in healthy and pathological tissues has historically led to the identification of oncogenes and tumor suppressor genes. It is very common that studies investigating loss of heterozygosity are carried out retrospectively on paraffin-embedded samples. METHODS: In this study, we evaluated the power of pyrosequencing for determining the loss of heterozygotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16958598
DOI: 10.1515/CCLM.2006.198

Genes

EMSY
PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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