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Article

Metallothionein-1A (MT1A) Gene Variability May Play a Role in Female Frailty: A Preliminary Study.

Genes - 26 Dec 2024

Crocco Paolina, De Rango Francesco, La Grotta Rossella, Passarino Giuseppe, Rose Giuseppina, Dato Serena

Abstract excerpt

BACKGROUND/OBJECTIVES: Frailty is a complex geriatric syndrome resulting in decreased physiological reserve. While genetics plays a role, the underlying mechanisms remain unsolved. Metallothioneins (MTs), metal-binding proteins with high affinity for zinc, an essential mineral for many physiological functions, are involved in processes including oxidative stress and inflammation. We investigated the impact of...

Read the complete abstract on PubMed

Topics

Humans
Female
Metallothionein
Aged
Male
Polymorphism, Single Nucleotide
Frailty

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged, 80 and over

Source

Open in PubMed Open full text

Identifiers

PMID: 39858562
DOI: 10.3390/genes16010015
PMCID: PMC11765288

Genes

MT1A
CRP
HGS
MT1B
MT2A
MT3

Variants

rs8052394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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