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Article

Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma.

Cell host & microbe - 19 Aug 2010

Saha Sukumar, Jing Xuefang, Park Shin Yong, Wang Shiyong, Li Xinna, Gupta Dipika, Dziarski Roman

Abstract excerpt

There are multiple mechanisms that protect the intestine from an excessive inflammatory response to intestinal microorganisms. We report here that all four mammalian peptidoglycan recognition proteins (PGRPs or Pglyrps) protect the host from colitis induced by dextran sulfate sodium (DSS). Pglyrp1(-/-), Pglyrp2(-/-), Pglyrp3(-/-), and Pglyrp4(-/-) mice are all more sensitive than wild-type mice to DSS-induced...

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Identifiers

PMID: 20709292
DOI: 10.1016/j.chom.2010.07.005
PMCID: PMC2998413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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