Article
Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.
Malaria journal - 9 Aug 2008
Ashley Elizabeth A, Pinoges Loretxu, Turyakira Eleanor, Dorsey Grant, Checchi Francesco, Bukirwa Hasifa, van den Broek Ingrid, Zongo Issaka, Urruta Pedro Pablo Palma, van Herp Michel, Balkan Suna, Taylor Walter R, Olliaro Piero, Guthmann Jean-Paul
Abstract excerpt
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy. METHODS: Data from different in vivo studies of ACT treatment of uncomplicated falciparum malaria were combined in a single database. Efficacy at day 28 corrected by PCR genotyping was...
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